P Pred

P Pred. p pred ratio) and predicted and p measured values is 7 A hypothesis that assumes no real difference between for be accepted or rejected? values (or ratio) is called is needs to (smaller than a threshold alpha lue 00 hypothesis reject A) A emate hypothesis Null Ho accepte e) H B) hypot and Alternate hypothesis [].

PolyPred DescriptionPolyPred Clinical PharmacologyIndications and Usage For PolyPredContraindicationsWarningsPrecautionsAdverse ReactionsPolyPred Dosage and AdministrationHow Is PolyPred SuppliedPolyPred®(prednisolone acetate neomycin sulfate polymyxin B sulfate ophthalmic suspension USP) is a topical antiinflammatory/antiinfective combination product for ophthalmic use with a pH of 50 70 and an osmolality of 260340 mOsm/kg Structural Formulas Corticosteroids suppress the inflammatory response to a variety of agents and they probably delay or slow healing Since corticosteroids may inhibit the body&#39s defense mechanism against infection a concomitant antimicrobial drug may be used when this inhibition is considered to be clinically significant in a particular case The antiinfective components in PolyPred® ophthalmic suspension are included to provide action against specific organisms susceptible to them Neomycin sulfate and polymyxin B sulfate are considered active against the following microorganisms Staphylococcus aureus Escherichia coli Hemophilus influenzae Klebsiella/ Enterobacter species Neisseria species and Pseudomonas aeruginosa When a decision to administer both a corticosteroid and an antimicrobial is made the administration of such drugs in combination has the advantage of greater patient compliance and convenience with the added assurance that the appropriate dosage of both drugs is administered A steroid/antiinfective combination is indicated for steroidresponsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial ocular infection exists Ocular steroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva cornea and anterior segment of the globe where the inherent risk of steroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation They are also indicated in chronic anterior uveitis and corneal injury from chemical radiation or thermal burns or penetration of foreign bodies The use of a combination drug with an antiinfective component is indicated where the risk of infection is high or where there is an expectation that potentially dangerous numbers of bacteria will be present in the eye The particular antiinfective drugs in this product are active against the following common bacterial eye pathogens Staphylococ Epithelial herpes simplex keratitis (dendritic keratitis) vaccinia varicella and many other viral diseases of the cornea and conjunctiva Mycobacterial infection of the eye Fungal diseases of the ocular structures Hypersensitivity to a component of the medication (Hypersensitivity to the antibiotic component occurs at a higher rate than for other components) The use of these combinations is always contraindicated after uncomplicated removal of a corneal foreign body NOT FOR INJECTION INTO THE EYE Prolonged use may result in glaucoma with damage to the optic nerve defects in visual acuity and fields of vision and in posterior subcapsular cataract formation Prolonged use may suppress the host response and thus increase the hazard of secondary ocular infections In those diseases causing thinning of the cornea or sclera perforations have been known to occur with the use of topical steroids In acute purulent conditions of the eye steroids may mask infection or enhance existing infection If these products are used for 10 days or longer intraocular pressure should be routinely monitored even though it may be difficult in children and uncooperative patients Employment of a steroid medication in the treatment of herpes simplex requires great caution There exists a potential for neomycin sulfate to cause cutaneous sensitization The exact incidence of this reaction is unknown The manifestations of sensitization to topical antibiotics are us General The initial prescription and renewal of the medication order beyond 20 milliliters should be made by a physician only after examination of the patient with the aid of magnification such as slit lamp biomicroscopy and where appropriate fluorescein staining The possibility of persistent fungal infections of the cornea should be considered after prolonged steroid dosing As with other antimicrobial preparations prolonged use may result in overgrowth of nonsusceptible organisms including fu Information for Patients If inflammation or pain persists longer than 48 hours or becomes aggravated the patient should be advised to discontinue use of the medication and consult a physician (See WARNINGS) This product is sterile when packaged To prevent contamination care should be taken to avoid touching the applicator tip to eyelids or to any other surface The use of this bottle by more than one person may spread infection Keep bottle tightly closed when not in use Keep out of the reach of children Patien Carcinogenesis Mutagenesis Impairment of Fertility No studies have been conducted in animals or in humans to evaluate the potential of these effects due to prednisolone Treatment of human lymphocytes invitrowith neomycin increased the frequency of chromosome aberrations at the highest concentration (80 μg/mL) tested however the effects of neomycin on carcinogenesis and mutagenesis in humans are unknown No studies have been conducted with polymyxin B sulfate to evaluate carcinogenic or mutagenic potential Polymyxin B has been reported to Adverse reactions have occurred with steroid/antiinfective combination drugs which can be attributed to the steroid component the antiinfective component or the combination Exact incidence figures are not available since no denominator of treated patients is available Reactions occurring most often from the presence of the antiinfective ingredients are allergic sensitizations including itching swelling and conjunctival erythema (see WARNINGS) More serious hypersensitivity reactions including anaphylaxis have been reported rarely The reactions due to the steroid component in decreasing order of frequency are elevation of intraocular pressure (IOP) with possible development of glaucoma and infrequent optic nerve damage posterior subcapsular cataract formation and delayed wound healing Although systemic effects are extremely uncommon there have been rare occurences of systemic hypercorticoidism after use of topical steroids Corticosteroidcontaining preparations hav TO TREAT THE EYE Instill 1 or 2 drops every 3 or 4 hours or more frequently as required Acute infections may require administration every 30 minutes with frequency of administration reduced as the infection is brought under control TO TREAT THE LIDS Instill 1 or 2 drops in the eye every 3 to 4 hours close the eye and rub the excess on the lids and lid margins Not more than 20 milliliters should be prescribed initially and the prescription should not be refilled without further evaluation as outlined in the PRECAUTIONSsection above PolyPred®(prednisolone acetate neomycin sulfate polymyxin B sulfate ophthalmic suspension USP) is supplied sterile in opaque white LDPE plastic bottles with droppers with white high impact polystyrene (HIPS) caps as follows 5 mL in 10 mL bottle – NDC0023002805 Note Store at 15 25˚C (59 77˚F) Protect from freezing Shake well before using Store in an upright position Rx Only Revised December 2004 © 2004 Allergan Inc Irvine CA 92612 USA ® Marks owned by Allergan Inc 6399X 71746US10P ALLERGAN NDC 0023002805 Rx Only PolyPred® (prednisolone acetate neomycin sulfate polymyxin B sulfate ophthalmic suspension USP) sterile 5 mL ALLERGAN NDC 0023002805 Rx Only PolyPred® (prednisolone acetate neomycin sulfate polymyxin B sulfate ophthalmic suspension USP) 5 mLsterile Medical Disclaimer.

Pred Forte Summary of Product Characteristics (SmPC) (emc)

Pred Forte 1% w/v Eye Drops Suspension 2 Qualitative and quantitative composition 1% w/v prednisolone acetate Excipient (s) with known effect Benzalkonium chloride 0006% w/v For the full list of excipients see section 61 3.

Protein Structure Prediction Server (PSIPRED)

Cendo PPred adalah sediaan steril tetes mata yang mengandung Prednisolon dan diproduksi oleh Cendo Obat ini diindikasikan sebagai pengobatan inflamasi atau peradangan pada mata Cendo PPred atau Prednisolon bekerja dengan cara mengurangi respons sistem kekebalan tubuh terhadap berbagai penyakit untuk mengurangi gejala seperti rasa sakit pembengkakan dan mata merah.

p pred ratio) and predicted and p measured values is 7 A

3D protein structure prediction from amino acid sequence Includes MEMSAT for transmembrane topology prediction GenTHREADER and mGenTHREADER for fold recognition.